|
Vascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Also, the availability of a common non-synonymous SNP can allow for testing of association of the CTH gene with biochemical traits affected by trans-sulfuration, such as plasma concentrations of homocysteine or even cystathionine itself, in addition to more downstream clinical phenotypes, such as vascular disease.
|
12574942 |
2003 |
|
Varicocele
|
0.010 |
Biomarker
|
disease |
BEFREE |
D,L-propargylglycine (PAG) was administrated to show the effects of cystathionine γ-lyase enzyme (CSE) inhibition in the varicocele.
|
31793716 |
2020 |
|
tumor vasculature
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Mutant cystathionine gamma-lyase was targeted to phosphatidylserine exposed on tumor vasculature through fusion with Annexin A1 or Annexin A5.
|
28522586 |
2017 |
|
Tremor
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Serum HDL cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Septicemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Hydrogen sulfide (H2S) is a gaseous mediator synthesized in mammalian tissues by three main enzymes-cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE), and 3-mercaptopyruvate-sulfurtransferase-and its levels increase under inflammatory conditions or sepsis.
|
25077524 |
2014 |
|
Septicemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Cystathionine-γ-lyase (CSE) isa hydrogen sulfide (H<sub>2</sub>S)-synthesizing enzyme that promotesinflammation by upregulating H<sub>2</sub>S in sepsis.
|
31261857 |
2019 |
|
Septicemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Cystathionine-γ-lyase gene silencing with siRNA in monocytes/ macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse.
|
26949091 |
2016 |
|
Sepsis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Cystathionine-γ-lyase (CSE) isa hydrogen sulfide (H<sub>2</sub>S)-synthesizing enzyme that promotesinflammation by upregulating H<sub>2</sub>S in sepsis.
|
31261857 |
2019 |
|
Sepsis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Cystathionine-γ-lyase gene silencing with siRNA in monocytes/ macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse.
|
26949091 |
2016 |
|
Sepsis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Hydrogen sulfide (H2S) is a gaseous mediator synthesized in mammalian tissues by three main enzymes-cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE), and 3-mercaptopyruvate-sulfurtransferase-and its levels increase under inflammatory conditions or sepsis.
|
25077524 |
2014 |
|
Seizures
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of CTH in PC3 cells results in the suppression of tumor growth and distant metastasis, while overexpression of CTH in DU145 cells promotes primary tumor growth and lymph node metastasis in the orthotopic implanted xenograft mouse model.
|
31468690 |
2019 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis.
|
29844591 |
2019 |
|
Retinal Neovascularization
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Hydrogen Sulfide Contributes to Retinal Neovascularization in Ischemia-Induced Retinopathy.
|
27273718 |
2016 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We used mice genetically deficient in the cystathionine γ-lyase enzyme (CSE), the major H<sub>2</sub>S-generating enzyme in the lung to determine the contribution of H<sub>2</sub>S to airway disease in response to side-stream tobacco smoke (TS), and to TS/RSV co-exposure.
|
30986815 |
2019 |
|
Renal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hydrogen sulfide-producing cystathionine γ-lyase is critical in the progression of kidney fibrosis.
|
28842346 |
2017 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Clinical data further reveal that the expression of CTH is elevated in late-stage prostate cancer patients, and higher CTH expression correlates with poor survival from The Cancer Genome Atlas (TCGA) prostate cancer RNA-seq datasets.
|
31468690 |
2019 |
|
Polyuria
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Inhibition of both cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS), 2 major enzymes for endogenous H<sub>2</sub>S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.
|
30036087 |
2019 |
|
Other cataract
|
0.200 |
Biomarker
|
disease |
RGD |
Age-associated oxidative damage leads to absence of gamma-cystathionase in over 50% of rat lenses: relevance in cataractogenesis.
|
15683713 |
2005 |
|
Osteoporosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In our previous in vivo study, impaired expression in MSCs of cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE), the two key enzymes in the catabolic pathway of homocysteine, was associated to decreased bone formation and to the onset of osteoporosis in mice.
|
28121025 |
2017 |
|
Neuromuscular inhibition
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that tobacco smoke influenced smooth muscle relaxation by decreasing H2S levels and this effect could also influence expression of cystathionine γ-lyase (CSE) and sulfonylurea receptor-2 (SUR-2).
|
28177058 |
2017 |
|
Neuromuscular inhibition
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In colonic smooth muscle from rabbit, mouse, and human, l-cysteine, substrate of cystathionine-γ-lyase (CSE), or NaHS, an H<sub>2</sub>S donor, inhibited phosphodiesterase 5 (PDE5) activity and augmented the increase in cGMP levels, IP<sub>3</sub> receptor phosphorylation at Ser<sup>1756</sup> (measured as a proxy for PKG activation), and muscle relaxation in response to NO donor <i>S-</i>nitrosoglutathione (GSNO), suggesting augmentation of cGMP/PKG pathway by H<sub>2</sub>S.
|
28705807 |
2017 |
|
Neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The expression and activity of CBS, CTH, and MPST were detected in the human glioblastoma-astrocytoma (U-87 MG) and neuroblastoma (SHSY5Y) cell lines.
|
28291844 |
2017 |
|
Neuroblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Intravenous administration of PEGylated hCGL-NLV in mice reduced serum l-Met from 123 μM to <5 μM for over 30 h. Importantly, treatment of neuroblastoma mouse xenografts with PEGylated hCGL-NLV resulted in near complete cessation of tumor growth.
|
22963240 |
2012 |